منابع مشابه
Bach2: plasma-cell differentiation takes a break.
Plasma cells are antibody-producing cells and represent the developmental end point of the B-cell lineage. Over the last few years, major progress has been made in understanding the transcriptional regulation of B-cell to plasmacell transition. Two transcription factors, Pax5 and Blimp1, are responsible for the development and maintenance of B-cell and plasma-cell identity, respectively. Both f...
متن کاملThe transcription factor BACH2 promotes tumor immunosuppression.
The immune system has a powerful ability to recognize and kill cancer cells, but its function is often suppressed within tumors, preventing clearance of disease. Functionally diverse innate and adaptive cellular lineages either drive or constrain immune reactions within tumors. The transcription factor (TF) BACH2 regulates the differentiation of multiple innate and adaptive cellular lineages, b...
متن کاملBACH2 promotes indolent clinical presentation in Waldenström macroglobulinemia
Approximately 30% of the patients who fulfil the criteria of Waldenström's macroglobulinemia (WM) are diagnosed while asymptomatic (indolent), and will not require immediate therapy. Conversely, patients with a disease-related event will be considered for therapy. The physiopathology of these 2 groups remains unclear, and the mechanisms of progression from indolent to symptomatic WM have yet to...
متن کاملTranscriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFNγ Regulation
Genetic studies have to date identified 43 genome wide significant coeliac disease susceptibility (CD) loci comprising over 70 candidate genes. However, how altered regulation of such disease associated genes contributes to CD pathogenesis remains to be elucidated. Recently there has been considerable emphasis on characterising cell type specific and stimulus dependent genetic variants. Therefo...
متن کاملExtended exome sequencing identifies BACH2 as a novel major risk locus for Addison's disease.
BACKGROUND Autoimmune disease is one of the leading causes of morbidity and mortality worldwide. In Addison's disease, the adrenal glands are targeted by destructive autoimmunity. Despite being the most common cause of primary adrenal failure, little is known about its aetiology. METHODS To understand the genetic background of Addison's disease, we utilized the extensively characterized patie...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2013
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri3580